منابع مشابه
Interstitial collagen catabolism.
Interstitial collagen mechanical and biological properties are altered by proteases that catalyze the hydrolysis of the collagen triple-helical structure. Collagenolysis is critical in development and homeostasis but also contributes to numerous pathologies. Mammalian collagenolytic enzymes include matrix metalloproteinases, cathepsin K, and neutrophil elastase, and a variety of invertebrates a...
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In this review, a clinical update is presented of the most important collagen vascular diseases (CVDs) and the different types of interstitial lung disease (ILD) encountered in these CVDs. These CVDs represent a heterogenous group of immunologically mediated inflammatory disorders with a large variety of affected organs besides the lungs. The frequency, clinical presentation, prognosis and resp...
متن کاملFrom clot to collagen: coagulation peptides in interstitial lung disease.
The fragile architecture of the lung is constantly threatened by a barrage of insults originating from both air and blood interfaces. The necessity to protect our lungs has lead to the evolution of exquisite defence systems. These comprise a complex screen of antioxidants, a mucocilliary escalator which is constantly clearing the respiratory tract and sophisticated immune defence mechanisms. Wh...
متن کاملexpression of collagen 1 and elastin genes in mitral valvular interstitial cells within microfiber reinforced hydrogel
objective: the incidence of heart valve disease is increasing worldwide and the number of heart valve replacements is expected to increase in the future. by mimicking the main tissue structures and properties of heart valve, tissue engineering offers new options for the replacements. applying an appropriate scaffold in fabricating tissue-engineered heart valves (tehvs) is of importance since it...
متن کاملPlasma prolidase activity: a possible index of collagen catabolism in chronic liver disease.
We describe here an easy method of determining prolidase (EC 3.4.13.9) in plasma after preincubation with Mn2+ for 24 h at 37 degrees C to maximize prolidase activity. The mean activity in 338 patients who were either in hospital or outpatients was 900 U/L +/- 520 (2 SD), unrelated to sex or age. In 25 of these 338 samples tested, prolidase activity was between 1500 and 2000 U/L. It exceeded 20...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2013
ISSN: 0021-9258
DOI: 10.1074/jbc.r113.451211